Protein Details: Amiloride-sensitive sodium channel subunit gamma
Protein ID
ICDB_Pro_0149
Protein Name
Amiloride-sensitive sodium channel subunit gamma
Gene Name
scnn1g; enacgamma
Organism
Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Length
653 amino acids
AlphaFoldDB
AF-H1AFJ7-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.
Sequence
MGHGRRISESIKKQLPVTGPEAPTVKNLMDWYLNNTNTHGCRRIAVSRGYLRRWIWICFTVSSVGMIFWQWTLLLMSYYTVSVSVTVQFQTLPFPAVTICNINPYRKNATSALLEELDKQTKLILKELYTSCTGCSNRKLRSVLLNEAPEEDSGVAKLLQDMPLMKFEVIKEDHVIVSELSSNRQYRINNTFITRMYNNMDLATVGEQVGFKICDANKSNCIIYTFNSGVTAILEWYRLNYLNIMAQIPNEKKLEMGYSADDLIVTCMYDGQSCDSRNFTLFQHPLHGNCYTFNSGDDGNILQTLTGGSEYGLKLTLYLENDDYNPYLFTSMGAKIIVHDQTEYPLVDDVGLEIQTATETLIGLQVTTSAKLSKPYSDCTMDGSDVLEQNLYNTSYSLQICLHSCFQTEMISNCGCAYYEQPLPSGAEYCYYEKYPGWIYCYYQLQDKFVNERLACQDICKETCNSKDWDLTKSLARWPSVASKDWVLNLLNWERGLNNTLNKNDLASIAIFYQDLNLRSLSESPANSIATLLSNMGGQLGLWMSCSIVCFLEMWEVFLVDILTIIARYWLHRGRQWWRKRKERQMQQPSPPDHDTGHHNPVCIDDEDPPTFHTAMQLPCVQTGPVPSTPPPQYNALRIQSVFDEQVSDTEVN
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Strongly expressed in gill; liver; kidney and rectum and more weakly in heart; muscle and intestine
DOI ID
10.1098/rspb.2012.1945